ブックタイトル神戸女子大学家政学部紀要 第50巻

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神戸女子大学家政学部紀要 第50巻

-11-Bulletin of the Faculty of Home Economics Kobe Women's University,50,11-16,2017Effect of Intake of Milk on Blood Leucine Level andBody Fat Mass in the Japanese ElderlyMichiyo KANEKO1, Takehiko KANEKO21Department of Home Economics, Kobe Women’s University2-1 Aoyama, Higashisuma, Suma-ku, Kobe, Hyogo Prefecture 654-8585, Japan2Department of Health and Nutrition, Wayo Women’s University2-3-1 Konodai, Ichikawa-shi, Chiba Prefecture 272-8533, JapanAbstractBackground: Sarcopenia is age-associated loss of skeletal muscle mass and muscle function leading to frailty,insulin resistance and type2 diabetes in the elderly. It is a critical challenge to prevent sarcopenia to extend healthylife expectancy in the rapidly aging Japanese society. Objective: This study was carried out to examine the impact ofthe intake of milk containing branched chain amino acids (BCAA) including leucine, isoleucine and valine, whichis the main amino acid of skeletal muscle on serum and body composition. Participants: Subjects were 22 healthyfemale and male aged from 67 to 87 years who gave consent to participate in the present study. Measurements:Blood analysis and body composition were compared between before and after the intake of milk for two months.Nutrient intake was analyzed by brief-type self-administered diet history questionnaire (BDHQ). Results: Leucinein serum (115.9±25.4nmol/ml) increased significantly after intake of milk (128.6±21.3nmol/ml) (p<0.05). Weight(56.8±9.8kg), body mass index (BMI) (24.1±2.2kg/m2), fat mass (18.5±4.3kg), body fat percentage (32.6±5.4%),and the intake of cereal (433.7±203.3g/day) decreased significantly after the intake of milk (55.4±9.6kg, 23.5±2.2kg/m2, 17.1±4.5kg, 30.8±6.0%, 346.1±133.7g/day, respectively) (p<0.05). Muscle mass had no change after theintake of milk. Conclusions: Intake of milk for two months significantly increased leucine in serum, and decreasedfat mass, though muscle mass had no change in the Japanese elderly.Key words; milk, leucine, fat mass, Japanese elderlyIntroductionIt is known that muscle mass in eighties isalmost half of that in forties1). This age-associatedloss of muscle mass and declining muscle functioncalled sarcopenia impaired the physical activityand independence which would causes frailty anddecreasing quality of life in the elderly2). The loss ofmuscle mass would also be a pathogenic factor forinsulin resistance and type2 diabetes which mightcause mortal diabetic complications as coronary heartdisease, diabetic nephropathy and cerebrovasculardisease3,4).Sarcopenia is caused by multiple age-relatedfactors such as declining in nervous system andhormone secretion, deterioration of muscle cellproliferation, physical inactivity due to chronic disease,insufficient intake of energy and protein5). Sarcopeniarefers to low lean mass, but sarcopenia can occur alsoin the overweight by excessive nutrient intake whichis called sarcopenia-obesity. It exacerbates the declineof muscle mass and strength due to physical inactivity,and it worsens insulin resistance and the risk of type2diabetes6).The effective treatments for sarcopenia aretaking resistance exercise, sufficient nutrition, andthe prevention of chronic disease which wouldcause inactivity and frailty7,8). Since branched chainamino acids (BCAA) including leucine, valine andisoleucine are main amino acids of skeletal muscle,muscle protein synthesis is regulated by BCAA,especially leucine, it could be considered that theintake of leucine combined with resistance exerciseis an effective treatment for sarcopenia with muscle